Piezo1 (Piezo-Type Mechanosensitive Ion Channel Component 1)-Mediated Mechanosensation in Macrophages Impairs Perfusion Recovery After Hindlimb Ischemia in Mice.

Lan XieXiying WangYuankun MaHong MaJian ShenJinyong ChenYidong WangSheng'an SuKaijie ChenLingxiao XuYao XieMeixiang Xiang

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

This study uncovers a crucial role of microenvironmental stiffness in exacerbating the macrophage-dependent deficient angiogenic response. Deletion of macrophage Piezo1 promotes perfusion recovery after hindlimb ischemia through CaMKII/ETS1-mediated transcriptional activation of FGF2. This provides a promising therapeutic strategy to enhance angiogenesis in ischemic diseases.

Keyphrases

transcription factor
adipose tissue
contrast enhanced
endothelial cells
gene expression
high fat diet induced
magnetic resonance imaging
vascular endothelial growth factor
wild type
oxidative stress
ischemia reperfusion injury
insulin resistance
wound healing
subarachnoid hemorrhage