Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model.
Hyun Jung ParkJuhyun JeonJiwoo ChoiJi Yeon KimHyun Sook KimJi Young HuhSteven A GoldmanJihwan SongPublished in: Cell proliferation (2021)
Altogether, these results strongly suggest that iPSC-NPCs transplantation induces neuroprotection and functional recovery in a mouse model of HD and should be taken forward for clinical trials in HD patients.
Keyphrases
- mouse model
- clinical trial
- induced pluripotent stem cells
- end stage renal disease
- cell therapy
- induced apoptosis
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- single cell
- stem cells
- bone marrow
- oxidative stress
- endoplasmic reticulum stress
- patient reported outcomes
- patient reported
- cell death
- open label