Equilibrium of the intracellular redox state for improving cell growth and L-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping.

Jian-Zhong XuHao-Zhe RuanXiu-Lai ChenFeng ZhangWeiguo Zhang

Published in: Microbial cell factories (2019)

This is the first report of balancing the intracellular redox state by switching the nucleotide-cofactor specificity of GAPDH and IDH, thereby improving cell growth and L-lysine production.

Keyphrases

reactive oxygen species
molecular dynamics
low grade
molecular dynamics simulations
electron transfer
wild type