Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging.
Muhammad Hamza GhafoorBen-Li SongLei ZhouZeng-Ying QiaoHao WangPublished in: ACS biomaterials science & engineering (2024)
Cancer is a severe threat to humans, as it is the second leading cause of death after cardiovascular diseases and still poses the biggest challenge in the world of medicine. Due to its higher mortality rates and resistance, it requires a more focused and productive approach to provide the solution for it. Many therapies promising to deliver favorable results, such as chemotherapy and radiotherapy, have come up with more negatives than positives. Therefore, a new class of medicinal solutions and a more targeted approach is of the essence. This review highlights the alluring properties, configurations, and self-assembly of peptide molecules which benefit the traditional approach toward cancer therapy while sparing the healthy cells in the process. As targeted drug delivery systems, self-assembled peptides offer a wide spectrum of conjugation, biocompatibility, degradability-controlled responsiveness, and biomedical applications, including cancer treatment and cancer imaging.
Keyphrases
- cancer therapy
- papillary thyroid
- high resolution
- drug delivery
- cardiovascular disease
- squamous cell
- induced apoptosis
- locally advanced
- type diabetes
- radiation therapy
- cell cycle arrest
- squamous cell carcinoma
- early onset
- lymph node metastasis
- metabolic syndrome
- cell death
- radiation induced
- signaling pathway
- endoplasmic reticulum stress
- fluorescence imaging
- cell proliferation