Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway.
Yi ZhangShaohua YangXiao CuiJuhong YangMiaoyan ZhengJunya JiaFei HanXiaoyun YangJingyu WangZhenhong GuoDong ChenBao Cheng ChangPublished in: Journal of diabetes research (2019)
In contrast to DKD, the renal structural damage and functional changes in the IGT stage, in which we propose the term "IGT kidney disease," mainly manifest as renal tubular injury. Insulin resistance and compensatory hyperinsulinemia may be involved in its pathogenesis.
Keyphrases
- pi k akt
- signaling pathway
- insulin resistance
- cell proliferation
- cell cycle arrest
- adipose tissue
- epithelial mesenchymal transition
- induced apoptosis
- type diabetes
- metabolic syndrome
- preterm infants
- oxidative stress
- magnetic resonance
- high fat diet
- skeletal muscle
- cell death
- gestational age
- endoplasmic reticulum stress
- high fat diet induced