Cyclosporine A-enhanced cardioplegia preserves mitochondrial basal respiration after ischemic arrest.

Alexandro A HoyerKristin KlaeskeJack GarnhamPhilipp KieferAida SalamehKlaus WitteMichael BorgerMaja-Theresa Dieterlen

Published in: Perfusion (2021)

Supplementing cardioplegic solutions with CsA enhances the basal mitochondrial respiration thereby exerting a cardioprotective effect and diminishing IRI-induced damage. CsA seems to preserve mitochondrial function via non-ROS related pathways.

Keyphrases

oxidative stress
diabetic rats
dna damage
high glucose
cell death
drug induced
reactive oxygen species
cell cycle
cell proliferation
cerebral ischemia
stress induced
brain injury
subarachnoid hemorrhage