PKC-δ Promotes IL-1β-Induced Apoptosis of Rat Chondrocytes and Via Activating JNK and P38 MAPK Pathways.

Jinfeng LuMiao YuJia Li

Published in: Cartilage (2023)

PKC-δ activation by IL-1β in OA promotes chondrocyte apoptosis via activation of the JNK and p38 MAPK signal pathways, thereby promoting the OA progression.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell death
knee osteoarthritis
pi k akt
cell cycle arrest
protein kinase
cell proliferation