SARS-CoV-2 and interferon blockade.
Betty DiamondBruce T VolpeSonya VanPattenYousef Al AbedPublished in: Molecular medicine (Cambridge, Mass.) (2020)
The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.