Shared Genetic Architecture between Parkinson's Disease and Brain Structural Phenotypes.

Dong-Rui MaShuang-Jie LiJing-Jing ShiYuan-Yuan LiangZheng-Wei HuXiao-Yan HaoMeng-Jie LiMeng-Nan GuoChun-Yan ZuoWen-Kai YuCheng-Yuan MaoMi-Bo TangChan ZhangYu-Ming XuJun WuShi-Lei SunChang-He Shi

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

We confirmed the polygenic overlap with mixed directions of allelic effects between PD and BSPs and identified multiple shared genomic loci and risk genes, which are likely related to immune-related biological processes. These findings provide insight into the complex genetic architecture associated with PD. © 2023 International Parkinson and Movement Disorder Society.

Keyphrases

genome wide
copy number
dna methylation
white matter
resting state
functional connectivity
drug induced
blood brain barrier
subarachnoid hemorrhage
breast cancer risk