Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice.

Lilian BassoMehdi BenamarXavier Mas-OreaCéline DeraisonCatherine BlanpiedNicolas CenacAbdelhadi SaoudiGilles Dietrich

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

Opioid-mediated analgesic activity of mucosal T lymphocytes remains operating in IL-10-/- mice with impaired immune regulation. The data suggest that endogenous T cell-derived opioids might reduce inflammation-induced abdominal pain in inflammatory bowel diseases associated with homozygous "loss of function mutations" in interleukin-10.

Keyphrases

chronic pain
pain management
abdominal pain
oxidative stress
diabetic rats
neuropathic pain
high glucose
insulin resistance
drug induced
type diabetes
spinal cord injury
endothelial cells
ulcerative colitis
big data
data analysis
wild type
stress induced