Effect of metformin on reducing platelet dysfunction in gestational diabetes mellitus: a randomized controlled trial.

Panisa HantrakunRattanaporn SekararithiThidarat JaiwongkamSirinart KumfuChatree Chai-AdisaksophaNipon ChattipakornTheera TongsongPhudit Jatavan

Published in: Endocrine connections (2022)

Metformin, in addition to diet and lifestyle modifications, does not improve or worsen oxidative stress and platelet dysfunction in women with GDM. Nevertheless, metformin significantly reduces fetal weight in women with GDM, theoretically preventing macrosomia.

Keyphrases

oxidative stress
weight loss
physical activity
pregnant women
dna damage
cardiovascular disease
metabolic syndrome
body mass index
ischemia reperfusion injury
induced apoptosis
weight gain
type diabetes
signaling pathway
heat shock