Aspirin is a commonly used nonsteroidal anti-inflammatory drug, associated with many adverse effects. The adverse effects of aspirin such as tinnitus, Reye's syndrome and gastrointestinal bleeding are caused due to conversion of aspirin into its active metabolite salicylic acid after oral intake. Glutathione is a naturally occurring antioxidant produced by the liver and nerve cells in the central nervous system. It helps to metabolize toxins, break down free radicles, and support immune function. This study aims to investigate and explore the possibility of inhibiting aspirin to salicylic acid conversion in presence of glutathione at a molecular level using spectroscopic techniques such as UV-Visible absorption, time-Resolved and time-dependent fluorescence and theoretical DFT/ TD-DFT calculations. The results of steady state fluorescence spectroscopy and time-dependent fluorescence indicated that the aspirin to salicylic acid conversion is considerably inhibited in presence of glutathione. Further, the results presented here might have significant clinical implications for individuals with variations in glutathione level.
Keyphrases
- low dose
- single molecule
- cardiovascular events
- antiplatelet therapy
- density functional theory
- molecular docking
- anti inflammatory
- energy transfer
- anti inflammatory drugs
- induced apoptosis
- signaling pathway
- percutaneous coronary intervention
- emergency department
- type diabetes
- molecular dynamics simulations
- high resolution
- physical activity
- weight loss
- case report
- endoplasmic reticulum stress
- weight gain
- mass spectrometry