Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature.

Patrick CoitXiavan RoopnarinesinghLourdes Ortiz-FernándezKathleen McKinnon-MaksimowiczEmily E LewisJoan T MerrillW Joseph McCuneJonathan D WrenAmr Hakam Sawalha

Published in: Annals of the rheumatic diseases (2022)

The lupus defining epigenetic signature, characterised by robust hypomethylation of interferon-regulated genes, does not appear to be determined by genetic factors. Hypomethylation of the miR-17-92 cluster that plays an important role in T cell activation is a novel epigenetic locus for lupus.

Keyphrases

dna methylation
systemic lupus erythematosus
genome wide
disease activity
cell proliferation
gene expression
long non coding rna
rheumatoid arthritis
copy number
dendritic cells