Insulin-like growth factor 2 mRNA-binding protein 2-regulated alternative splicing of nuclear factor 1 C-type causes excessive granulosa cell proliferation in polycystic ovary syndrome.
Feiyan ZhaoLiang WuQin WangXuehan ZhaoTong ChenCheng-Hong YinLong YanXiaokui YangPublished in: Cell proliferation (2022)
In conclusion, we demonstrated that IGF2BP2 promotes GC proliferation via regulating alternative splicing of NFIC in PCOS. The findings help to better understand the roles of IGF2BP2 in the pathogenesis of PCOS.
Keyphrases
- polycystic ovary syndrome
- binding protein
- nuclear factor
- cell proliferation
- toll like receptor
- insulin resistance
- growth hormone
- pi k akt
- signaling pathway
- weight gain
- transcription factor
- type diabetes
- adipose tissue
- skeletal muscle
- metabolic syndrome
- immune response
- gas chromatography
- body mass index
- high resolution
- weight loss