Login / Signup

Evaluation of the impact of repeated intravenous phage doses on mammalian host-phage interactions.

Xin TanKai ChenZhihuan JiangZiqiang LiuSiyun WangYong YingJieqiong ZhangShengjian YuanZhipeng HuangRuyue GaoMin ZhaoAoting WengYongqing YangHuilong LuoDaizhou ZhangYing-Fei Ma
Published in: Journal of virology (2023)
Phage therapy has demonstrated potential in addressing multidrug-resistant bacterial infections. However, an insufficient understanding of phage-host interactions has impeded its broader clinical application. In our study, specific phages were administered intravenously (IV) to both rats and monkeys to elucidate phage-host interactions and evaluate phage pharmacokinetics (PK). Results revealed that with successive IV administrations, there was a decrease in plasma phage concentrations. Concurrently, these administrations elicited both innate and adaptive immune responses in the subjects. Notably, the observed immune responses and PK profiles exhibited variation contingent upon the phage type and the mammalian host. Despite these variations, the tested mammals exhibited a favorable tolerance to the IV-administered phages. This underscores the significance of comprehending these interactions for the optimization of phage therapy outcomes.
Keyphrases
  • pseudomonas aeruginosa
  • immune response
  • multidrug resistant
  • cystic fibrosis
  • acinetobacter baumannii
  • stem cells
  • type diabetes
  • metabolic syndrome
  • dendritic cells
  • inflammatory response
  • weight loss