Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching.

Virginia ChamorroDaniel Morales-CanoJavier MilaraBianca BarreiraLaura MorenoMaría CallejoGema Mondejar-ParreñoSergio Esquivel-RuizJulio CortijoÁngel CogolludoJoan A BarberáFrancisco Pérez Vizcaíno

Published in: PloS one (2018)

PDE5 inhibitors and sGC stimulators show a different vasodilator profile. Riociguat was highly effective and potentiated by hypoxia in rat and human PA. In vivo, riociguat preferentially inhibited hypoxic than non-hypoxic vasoconstriction. However, it did not worsen V'/Q' coupling in a rat model of pulmonary fibrosis.

Keyphrases

pulmonary hypertension
pulmonary fibrosis
endothelial cells
pulmonary arterial hypertension
oxidative stress
induced pluripotent stem cells
respiratory failure
mechanical ventilation
intensive care unit
computed tomography