Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice.

Madelyn C HuangCynthia J WillsonSridhar JaligamaGregory L BakerAlan W SingerYu CaoJessica PierfeliceEsra MutluBrian BurbackGuanhua XieDavid E MalarkeyBarney SparrowKristen RyanMatthew StoutGeorgia K Roberts

Published in: Inhalation toxicology (2022)

Nasal lesions were observed in all animals after whole-body exposure up to 600 ppm 2-ET for 2 weeks. Future studies should focus on 2-ET metabolism and distribution to better understand species differences and refine hazard characterization of this understudied environmental contaminant.

Keyphrases

chronic rhinosinusitis
gestational age
current status
high fat diet induced
human health
metabolic syndrome
insulin resistance