Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis-Induced Acute Kidney Injury.

Qiong-Yuan Hu Jian-An RenHuajian RenJie WuXiuwen Wu Song LiuGefei WangGuosheng GuKun GuoJieshou Li

Published in: Oxidative medicine and cellular longevity (2018)

An elevated UmtDNA level correlates with mitochondrial dysfunction and renal injury in sepsis patients, indicating renal mitochondrial injury induced by sepsis. Therefore, UmtDNA may be regarded as a valuable biomarker for the occurrence of AKI and the development of mitochondria-targeted therapies following sepsis-induced AKI.

Keyphrases

acute kidney injury
cardiac surgery
mitochondrial dna
oxidative stress
diabetic rats
septic shock
end stage renal disease
intensive care unit
copy number
high glucose
chronic kidney disease
ejection fraction
newly diagnosed
risk assessment
peritoneal dialysis
genome wide
patient reported