PD-L1-expression patterns in large-cell neuroendocrine carcinoma of the lung: potential implications for use of immunotherapy in these patients: the GFPC 03-2017 "EPNEC" study.

Dominique ArpinMarie-Christine CharpentierMarie BernardiIsabelle MonnetAurelie BoniEmmanuel WatkinIsabelle Goubin-VersiniRégine LamyLaurence GérinièreMargaux GeierFabien ForestRadj GervaisAnne MadrosykFlorian GuisierCécile SerrandChrystèle LocherChantal DecroisettePierre FournelJean-Bernard AuliacThierry JeanfaivreJacques LetreutHélène DoubreGeraldine FrancoisNicolas PitonChristos ChouaidDiane Damotte

Published in: Therapeutic advances in medical oncology (2020)

TC-/IC+ was the most frequent PD-L1-expression profile for LCNECs, a pattern quite specific compared with non-small-cell lung cancer and small-cell lung cancer. IC PD-L1 expression seems to have a prognostic role.

Keyphrases

small cell lung cancer
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
stem cells
mesenchymal stem cells
bone marrow