CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27kip1 Axis.

Xin ZhouTian-Man Li Jian-Zhu LuoChen-Lu LanZhong-Liu WeiTian-Hao FuXi-Wen LiaoGuang-Zhi ZhuXin-Ping YeTao Peng

Published in: Journal of hepatocellular carcinoma (2021)

The results demonstrated that CYP2C8 enhances the anticancer activity of sorafenib in vitro assays and in tumor xenograft model, with Ki-67 down-regulation and PI3K/Akt/p27Kip1 axis inhibition. In conclusion, these findings hinted that CYP2C8 restricted malignant phenotype and sorafenib resistance in HCC via PI3K/Akt/p27kip1 axis.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
squamous cell carcinoma
high throughput
radiation therapy
neoadjuvant chemotherapy
cell death