A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.

Ellen L RisembergJohanna M SmeekensMarta C Cruz CisnerosBrea K HamptonPablo HockColton L LinnertzDarla R MillerKelly OrgelGinger D ShawFernando Pardo Manuel de VillenaA Wesley BurksWilliam ValdarMichael D KulisMartin T Ferris

Published in: The Journal of allergy and clinical immunology (2024)

Our results demonstrate a key role for Themis in the orally reactive CC027 mouse model of peanut allergy.

Keyphrases

mouse model
high fat diet induced
atopic dermatitis
type diabetes
metabolic syndrome