POPs' effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertension.
Ana FerroDiana TeixeiraDiogo PestanaRosário MonteiroCristina Maria Nogueira da Costa SantosValentina Fernandes DominguesJorge PolóniaConceição CalhauPublished in: Archives of environmental & occupational health (2018)
Persistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ∑HCH and ∑POPs in vAT were significantly higher in treated women. VAT ∑HCH and scAT ∑HCH and ∑POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.
Keyphrases
- postmenopausal women
- blood pressure
- insulin resistance
- polycystic ovary syndrome
- weight loss
- adipose tissue
- bariatric surgery
- hypertensive patients
- metabolic syndrome
- high fat diet induced
- type diabetes
- heart rate
- weight gain
- high fat diet
- skeletal muscle
- oxidative stress
- heart failure
- blood glucose
- newly diagnosed
- pregnant women
- breast cancer risk
- mass spectrometry
- atomic force microscopy
- single molecule