Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation.
A R SousaR P MarshallL C WarnockS BoltonA HastieF SymonB HargadonH MarshallM RichardsonC E BrightlingP HaldarR MiloneP ChalkR WilliamsonR PanettieriR KnowlesE R BleeckerAndrew John WardlawPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
Disease severity does not influence the response to systemic corticosteroids. The study does not therefore support the concept that severe asthma is associated with corticosteroid resistance. Only baseline eosinophilic inflammation was associated with the physiological response to corticosteroids, confirming the importance of measuring eosinophilic inflammation to guide corticosteroid use.
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