Association of Microbial Dysbiosis with Gallbladder Diseases Identified by Bile Microbiome Profiling.

Seong Ji Choi Yeseul Kim Jehyun Jeon Ho Jin Gwak Mi Mi Kim Kyojin Kang Yohan Kim Jaemin Jeong Yun Kyung Jung Kyeong Geun Lee Ho Soon Choi Dong Hwan Jung Sung Gyu Lee Yangsoon Lee Su-Jin Shin Ki Seok Jang Mina Rho Dongho Choi

Published in: Journal of Korean medical science (2021)

We investigated the bile microbiome in normal, chronic cholecystitis, and gallbladder cancer. We suggest possible roles of Enterobacteriaceae, including Klebsiella, in gallbladder carcinogenesis. Our findings reveal a possible link between a dysbiotic bile microbiome and the development of chronic calculous cholecystitis and gallbladder cancer.

Keyphrases

papillary thyroid
squamous cell
single cell
pseudomonas aeruginosa
multidrug resistant
microbial community
genome wide
escherichia coli
squamous cell carcinoma
lymph node metastasis
young adults
dna methylation
childhood cancer
cystic fibrosis
atomic force microscopy