IRF4 rearrangement may predict favorable prognosis in children and young adults with primary head and neck large B-cell lymphoma.

Xiang-Nan JiangFang YuTian XueQing-Xin XiaQian-Ming BaiBao-Hua YuRuo-Hong ShuiXiao-Yan ZhouXiong-Zeng ZhuJun-Ning CaoXiao-Nan HongXiao-Qiu Li

Published in: Cancer medicine (2023)

Our work confirmed the unique clinicopathologic features of LBCL, IRF4+, and disclosed for the first time the independent favorable prognostic impact of IRF4+. These findings may further unravel the heterogeneity of LBCL occurring in youth, and aid in risk stratification and tailoring the therapeutic strategy.

Keyphrases

young adults
dendritic cells
childhood cancer
single cell
diffuse large b cell lymphoma