Iodine-Mediated δ-Amination of sp 3 C-H Bonds.

We present a direct δ-amination reaction of sp 3 C-H bonds, employing molecular iodine (I 2 ) as the sole oxidant under transition-metal-free conditions. This remote C-H functionalization approach is operationally simple and provides facile, efficient access to pyrrolidines and related heterocyclic derivatives from readily accessible substrates.