Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer's disease and vascular dementia.
Xin Ying ChuaFederico TortaJoyce R ChongNarayanaswamy VenketasubramanianSaima HilalMarkus R WenkChristopher P ChenThiruma V ArumugamDeron R HerrMitchell Kim Peng LaiPublished in: Alzheimer's research & therapy (2023)
AD and VaD are associated with distinct changes of plasma sphingolipids, warranting further studies into underlying pathophysiological mechanisms and assessments of their potential utility as dementia biomarkers and therapeutic targets.