Mechanisms Contributing to Acquired Activated Protein C Resistance in Patients Treated with Thalidomide: A Molecular Dynamics Study.
Correa Lara MaximilianoGarcía Chavez JaimeVega Lopez ArmandoLara Vega IsrraelHernandez Gonzalez VictoriaMartinez Hernandez ErikaPublished in: Cardiovascular & hematological disorders drug targets (2023)
We demonstrate the in silico inhibitory potential of thalidomide on APC, through two possible inhibition mechanisms, a pathophysiologically relevant finding to understand the factors that can affect the stability and functions of APC in vivo.