Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice.
Alexander NolzeConny KöhlerStefanie RuhsKatja QuarchNicole SträtzMichael GekleClaudia GrossmannPublished in: Acta physiologica (Oxford, England) (2021)
AngII-induced vascular remodelling involves PPP3CB, which leads to enhanced EMC production, VSMC migration and sustained increase in systolic blood pressure via HBEGF/EGFR-TGFβ-CTGF signalling.
Keyphrases
- angiotensin ii
- blood pressure
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- angiotensin converting enzyme
- vascular smooth muscle cells
- heart failure
- high glucose
- diabetic rats
- left ventricular
- heart rate
- transforming growth factor
- high fat diet induced
- blood glucose
- epithelial mesenchymal transition
- weight loss