Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy.

Martina OttCynthia KassabAnantha MarisettyYuuri HashimotoJun WeiDaniel B ZamlerJia-Shiun LeuKarl-Heinz TomaszowskiAria SabbaghDexing FangPravesh GuptaWaldemar PriebeRafal J ZielinskiJared K BurksJames P LongLing-Yuan KongGregory N FullerJohn DeGrootErik P SulmanAmy B Heimberger

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

This study indicates that the combination of STAT3 inhibition and WBRT enhances the therapeutic effect against gliomas in the CNS by inducing dendritic cell and T-cell interactions in the CNS tumor.

Keyphrases

dendritic cells
regulatory t cells
cell proliferation
blood brain barrier
immune response
stem cells
high grade
brain metastases