Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN-γ +874 A > T and CMV manifestations.

Stéphanie Gomes Santos de AlmeidaFabiana Batalha KnakcfussLívia Maria AssisRegina Celia Gonçalves de SousaTereza Azevedo MatuckDeise de Boni Monteiro de CarvalhoRicardo Luiz Dantas MachadoMaria Angelica Arpon Marandino GuimarãesRafael Brandão Varella

Published in: International journal of immunogenetics (2022)

We investigated the effects of TNF-α, IFN-γ, IL-10 polymorphisms on viral infections (CMV, BKPyV, HHV-6, EBV) after renal transplantation. IFN-γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate-based therapy and graft failure (p = .025). This study underscores the role of IFN-γ+874 SNP in CMV infection.

Keyphrases

dendritic cells
immune response
end stage renal disease
sars cov
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
epstein barr virus
gene expression
high speed