The origin of ovarian Leydig cells: a possibly solved enigma?

Jose Luis CarrascoMiriam González-GómezOlga TapiaSonia García-HernándezAbian Vega-FalcónRafael Méndez-MedinaHugo Álvarez-Argüelles CabreraLucio Díaz-Flores

Published in: Human cell (2024)

Over the years, the origin of ovarian Leydig cells has been, and still is, a topic subject to deep debate. Seven years ago, we proposed that this origin resided in intraneural elements that came from a possible reservoir of neural crest cells, a reservoir that may be located in the ganglia of the celiac plexus. We believe we have found the evidence necessary to prove this hypothesis.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
oxidative stress
cell death
cell proliferation