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Impact of the Recent Clinical and Laboratory Standards Institute Breakpoint Changes on the Antimicrobial Spectrum of Aminoglycosides and the Activity of Plazomicin Against Multidrug-Resistant and Carbapenem-Resistant Enterobacterales From United States Medical Centers.

Helio Silva SaderRodrigo Elisandro MendesJohn H KimbroughValerie KantroMariana Castanheira
Published in: Open forum infectious diseases (2023)
The spectrum of activity of amikacin against resistant subsets of Enterobacterales was drastically reduced when interpretative criteria based on pharmacokinetic/pharmacodynamic parameters that are currently used to establish breakpoints for other antimicrobials were applied. Plazomicin was markedly more active than amikacin, gentamicin, or tobramycin against antimicrobial-resistant Enterobacterales.
Keyphrases
  • multidrug resistant
  • staphylococcus aureus
  • healthcare
  • gram negative
  • peripheral blood
  • acinetobacter baumannii
  • escherichia coli
  • pseudomonas aeruginosa
  • cystic fibrosis