Functional Metallofullerene Materials and Their Applications in Nanomedicine, Magnetics, and Electronics.
Taishan WangChun-Ru WangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2019)
Endohedral metallofullerenes exhibit combined properties from carbon cages as well as internal metal moieties and have great potential in a wide range of applications as molecule materials. Along with the breakthrough of mass production of metallofullerenes, their applied research has been greatly developed with more and more new functions and practical applications. For gadolinium metallofullerenes, their water-soluble derivatives have been demonstrated with antitumor activity and unprecedented tumor vascular-targeting therapy. Metallofullerene water-soluble derivatives also can be applied to treat reactive oxygen species (ROS)-induced diseases due to their high antioxidative activity. For magnetic metallofullerenes, the internal electron spin and metal species bring about spin sensitivity, molecular magnets, and spin quantum qubits, which have many promising applications. Metallofullerenes are significant candidates for fabricating useful electronic devices because of their various electronic structures. This Review provides a summary of the metallofullerene studies reported recently, in the fields of tumor inhibition, tumor vascular-targeting therapies, antioxidative activity, spin probes, single-molecule magnets, spin qubits, and electronic devices. This is not an exhaustive summary and there are many other important study results regarding metallofullerenes. All of this research has revealed the irreplaceable role of metallofullerene materials.
Keyphrases
- human health
- single molecule
- water soluble
- climate change
- reactive oxygen species
- living cells
- atomic force microscopy
- room temperature
- density functional theory
- cancer therapy
- anti inflammatory
- cell death
- high resolution
- single cell
- transition metal
- high glucose
- drug delivery
- magnetic resonance imaging
- diabetic rats
- mass spectrometry
- endothelial cells
- drug induced
- ionic liquid
- smoking cessation
- monte carlo