Genome Profiling of H3k4me3 Histone Modification in Human Adipose Tissue during Obesity and Insulin Resistance.

Daniel Castellano-Castillo Bruno Ramos-Molina Wilfredo Oliva-OliveraLuis Ocaña-WilhelmiMaría Isabel Queipo-Ortuño Fernando Cardona

Published in: Biomedicines (2021)

In conclusion, we emphasize the importance of the epigenetic mark H3K4me3 in VAT dysfunction in obesity and IR. The understanding of such mechanisms could give rise to the development of new epigenetic-based pharmacological strategies to ameliorate obesity-related comorbidities.

Keyphrases

insulin resistance
adipose tissue
metabolic syndrome
weight loss
dna methylation
high fat diet induced
type diabetes
weight gain
gene expression
endothelial cells
high fat diet
oxidative stress
genome wide
single cell
induced pluripotent stem cells