Pharmacokinetic and safety assessment of carboplatin-impregnated calcium sulfate hemihydrate beads in eight rats.
Beatriz BeldaJosé Ramos-VaraKristen M MessengerMarije RisseladaPublished in: Veterinary surgery : VS (2021)
Piled CI-CSH bead implantation is well tolerated in rats with similar elution profile as previously described. Beads were radiographically visible at d28. Minimal Pt was detected systemically suggesting Pt release does not match bead dissolution.
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