Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy.
Yixin ChenSiyuan XiangLu WangMingyue WangCongcong WangShuwei LiuKai ZhangBai YangPublished in: ChemPlusChem (2018)
Polypyrrole (PPy) hollow nanostructures continue to attract the interest researchers because of their good biocompatibility, high photothermal conversion efficiency, and excellent stability. The preparation of PPy hollow nanostructures by the hard templating method without complicated post-synthetic treatment and additional oxidizing agents remains a challenge. In this work, we report a facile and novel hard templating method to fabricate hollow PPy nanospindles in which MIL-88(Fe) serves as the template. Fe3+ centers in MIL-88(Fe) could induce the polymerization of pyrrole to construct the shell, and MIL-88(Fe) would be decomposed by solvent water. This method did not require any extra oxidizing agents and post-synthetic treatment. Hollow PPy nanospindles exhibit excellent photothermal and drug loading ability, and the therapy effect of cancer was significant. This method provides a new hard templating approach for the synthesis of polymer hollow nanostructures.
Keyphrases
- metal organic framework
- molecularly imprinted
- cancer therapy
- solid phase extraction
- drug delivery
- photodynamic therapy
- emergency department
- stem cells
- high resolution
- combination therapy
- simultaneous determination
- reduced graphene oxide
- drug release
- tandem mass spectrometry
- adverse drug
- liquid chromatography
- tissue engineering