An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure for the quantification of levetiracetam in human serum and plasma.
Anja KobelTobias SchierscherNeeraj SinghLinda SalzmannFranziska LieschFriederike BaulandAndrea GeistangerLorenz RischChristian GeletnekyChristoph SegerJudith TaibonPublished in: Clinical chemistry and laboratory medicine (2023)
We present a novel LC-MS/MS)-based candidate RMP for levetiracetam in human serum and plasma. Its expanded measurement uncertainty of ≤4.0% meets the clinical needs in levetiracetam monitoring. Utilizing qNMR to characterize levetiracetam reference materials allowed metrological traceability to SI units.