Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity.

Tu-Xiong HuangXiang-Yu TanHui-Si HuangYu-Ting LiBei-Lei LiuKai-Sheng LiuXinchun ChenZhe ChenXin-Yuan GuanChang ZouLi Fu

Published in: Gut (2021)

CAFs could suppress antitumour immunity through WNT2 secretion. Targeting WNT2 might enhance the ICI efficacy and represent a new anticancer immunotherapy.

Keyphrases

cell proliferation
stem cells
dendritic cells
cancer therapy
drug delivery