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Colony-stimulating factor-1 receptor blockade attenuates inflammation in inflamed gingival tissue explants.

Reuben ClarkRonaldo Lira-JuniorGunnar JohannsenElisabeth Almer Boström
Published in: Journal of periodontal research (2021)
These results indicate that CSF-1R is elevated in PD, and its inhibition attenuates inflammatory mediators in the inflamed gingival tissue and circulating myeloid cells. Together these findings suggest that CSF-1R might be involved in regulating inflammatory processes in PD, and a potential therapeutic target to reduce the harmful inflammation.
Keyphrases
  • oxidative stress
  • induced apoptosis
  • cell cycle arrest
  • acute myeloid leukemia
  • dendritic cells
  • cell death
  • cerebrospinal fluid
  • human health
  • pi k akt