Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow.
Lin WangLi YanJieling JiangYuyi ZhangQiyu HeHui ZhuangLing WangPublished in: Emerging microbes & infections (2020)
Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence.
Keyphrases
- bone marrow
- end stage renal disease
- mesenchymal stem cells
- newly diagnosed
- endothelial cells
- ejection fraction
- chronic kidney disease
- liver failure
- acute myeloid leukemia
- sars cov
- prognostic factors
- respiratory failure
- hepatitis b virus
- intensive care unit
- patient reported outcomes
- acute lymphoblastic leukemia
- extracorporeal membrane oxygenation
- aortic dissection
- mechanical ventilation