Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats.

Mengying YaoDawei LianMeizhu WuYuting ZhouYi FangSiyu ZhangWenqiang ZhangYanyan YangRenfeng LiHong ChenYouqin ChenA-Ling ShenJun Peng

Published in: Drug design, development and therapy (2023)

This study showed that treatment with isoliensinine effectively reduced the renal injury and fibrosis in SHRs. In addition, isoliensinine inhibited the TGF-β1/Smad2/3 signaling in-vivo. These findings provided strong evidence for the therapeutic benefits of isoliensinine in combating renal injury and fibrosis.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
cell proliferation
combination therapy