Regional adiposity and insulin sensitivity - interactions with menopause and HIV in middle-aged Black African women.
Maphoko MasemolaAmy E MendhamLisa K MicklesfieldCarmen PheifferJames HawleyAndre Pascal KengneTinashe ChikoworeClement Nyuyki KufeNigel J CrowtherShane NorrisKarl-Heinz StorbeckTommy OlssonFredrik KarpeJulia H GoedeckePublished in: The Journal of clinical endocrinology and metabolism (2024)
Insulin sensitivity and beta cell function were distinctively associated with aSAT and gSAT. While menopause did not influence these relationships, HIV had a significant effect on adipose tissue, characterised by variations in cell size distribution and transcript levels within the depots.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- adipose tissue
- middle aged
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- insulin resistance
- men who have sex with men
- postmenopausal women
- polycystic ovary syndrome
- single cell
- high fat diet
- metabolic syndrome
- type diabetes
- pregnant women
- bone marrow
- skeletal muscle
- breast cancer risk