Blood neurofilament light chain levels are associated with disease progression in a transgenic SCA3 mouse model.

David MengelIsabel G Wellik Kristen H SchusterSabrina I JarrahMadeleine WackerNaila S AshrafGülin Öz Matthis Synofzik Maria do Carmo Costa Hayley S McLoughlin

Published in: bioRxiv : the preprint server for biology (2023)

Peripheral blood of SCA3 YACQ84 mice exhibits increased abundance of neuronal-specific NfL protein directly associating with disease progression, providing an accessible disease biofluid biomarker to interrogate in preclinical therapeutic studies.

Keyphrases

peripheral blood
mouse model
cerebrospinal fluid
high fat diet induced
case control
protein protein
amino acid
antibiotic resistance genes
stem cells
binding protein
type diabetes
metabolic syndrome
cerebral ischemia
brain injury
mesenchymal stem cells