Effect of HER2/CEP17 ratio on survival in metastatic HER2-positive gastric cancer, multicenter study.
Serhat SekmekIrfan KarahanGokhan UcarFurkan CeylanDogan BayramIsmet SevenHatice BölekYüksel ÜrünKadriye Bir YücelOzan YaziciAhmet KadiogluCengiz KaracinKubra CanaslanElif AtagSerhat DemirerGokmen Umut ErdemYakup ErgunMehmetcan AtakBaris KoksalMerve Meryem KiranDuriye Ozer TurkayBurak CivelekBulent YalcinDogan UncuPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
Patients with both high HER2 gene amplification and high HER2/CEP17 ratio had better OS. The PFS of the group with high HER2 gene amplification was also better. To our knowledge, this is the first study in the literature showing that the HER2/CEP17 ratio affects survival in patients with metastatic gastric cancer.