5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts.

Yuji OdagakiMasakazu KinoshitaJosé Javier Meana Luis F Callado Jesús A García-Sevilla

Published in: Pharmacological reports : PR (2021)

Our data demonstrate that the signaling pathways mediated by Gαq/11 proteins coupled with 5-HT2A receptors and M1 mAChRs in prefrontal cortex are functionally altered in opiate addicts in comparison with control subjects. These alterations may underpin some aspects of addictive behavior to opiate as well as neuropsychological consequences or comorbid mental disorders associated with opioid use.

Keyphrases

prefrontal cortex
signaling pathway
electronic health record
mild cognitive impairment
big data
epithelial mesenchymal transition
pi k akt
cell proliferation
binding protein
working memory
data analysis