Nucleus accumbens degeneration in spinocerebellar ataxia type 2: a preliminary study.

Kenjiro NakayamaKiyotaka NemotoTetsuaki Arai

Published in: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society (2024)

This study found that nucleus accumbens (NAc) atrophy was significantly accelerated in SCA2 patients. Anatomically, the NAc is densely connected with infratentorial brain regions, so it is reasonable to posit that degeneration propagates from the cerebellum and brainstem to the NAc and other supratentorial areas. Functionally, the NAc is essential for appropriate behaviour, so NAc degeneration might contribute to neuropsychological symptoms in SCA2 patients.

Keyphrases

transcription factor
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
physical activity
patient reported outcomes
early onset
genome wide analysis
brain injury