Exploring the potential molecular mechanism of Gualou Guizhi decoction in the treatment of rheumatoid arthritis based on network pharmacology and molecular docking.
Zhihao DuanCan JinShuai MaJinlang LiuShigang LiYou ZhouPublished in: Medicine (2024)
The therapeutic effect of GGD for RA is achieved by affecting the core targets such as VEGFA, IL-1β, IL6, CXCL8, CCL2, and JUN, which together interfere with the tumor necrosis factor signaling pathway and RA pathway to treat RA. The above study provides new ideas for further exploration of this classic formula in the future.
Keyphrases
- rheumatoid arthritis
- molecular docking
- disease activity
- signaling pathway
- ankylosing spondylitis
- interstitial lung disease
- molecular dynamics simulations
- pi k akt
- systemic lupus erythematosus
- current status
- systemic sclerosis
- oxidative stress
- liver fibrosis
- cell proliferation
- idiopathic pulmonary fibrosis
- endoplasmic reticulum stress
- replacement therapy