Histopathologic and molecular characterization of BAP-1-inactivated melanoma.

Elisabeth M Miller Konstantinos D Linos Carlos Eduardo Bacchi Alejandro A Gru Shyam Sampath Raghavan

Published in: Journal of cutaneous pathology (2022)

Herein we describe five cases of BAP-1-inactivated melanomas confirmed by histomorphology and immunohistochemistry, all of which show malignant copy number profiles including loss of 3p. In addition, we provide a case of a likely BIMT showing progression to BAP-1-inactivated melanoma on a 16-year follow-up.

Keyphrases

copy number
mitochondrial dna
genome wide
skin cancer
dna methylation
gene expression
basal cell carcinoma