FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats.

Hyder SaidYasutada AkibaKazuyuki NarimatsuKoji MarutaAyaka KuriKen-Ichi IwamotoAtsukazu KuwaharaJonathan D Kaunitz

Published in: Digestive diseases and sciences (2017)

These results suggest that luminal FFA3 activation enhances mucosal defenses and prevents NSAID-induced enteropathy via the GLP-2 pathway. The selective FFA3 agonist may be a potential therapeutic candidate for NSAID-induced enteropathy.

Keyphrases

high glucose
diabetic rats
drug induced
mouse model
oxidative stress